A Single Nucleotide Polymorphism in the Rad51 Gene in Colorectal Cancer
نویسندگان
چکیده
Received: September 27, 2002. *Correspondence. Fax: +48-42 635-44-84; E-mail: [email protected] The mammalian RAD51 gene is a homologue of the yeast RAD51 and E. coli RecA genes, which are involved in the genetic recombination the repair of DNA double-strand breaks, and SOS responses to DNA damage. RAD51 gene product (hRAD51, m.w. 37 kD) can bind to singleand double-stranded DNA and exhibit DNA-dependent ATPase activity [13]. OverA SINGLE NUCLEOTIDE POLYMORPHISM IN THE RAD51 GENE IN COLORECTAL CANCER
منابع مشابه
Lack of association between the 135G/C RAD51 gene polymorphism and the risk of colorectal cancer among Polish population.
One of the major causes of carcinogenesis is loss of genome stability. RAD51 in process of homologous recombination (HR) played crucial role in maintenance integrity of genome through initiate of DNA double strand breaks repair. Presence of single nucleotide polymorphism (SNP) in RAD51 gene could change the capacity of DNA repair and altered the response to damaging agents. Research on potentia...
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